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Mutation, Gene Flow, and Genetic Drift01:09

Mutation, Gene Flow, and Genetic Drift

In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).Mechanisms of Genetic VariationThe original sources of genetic variation are mutations,...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...

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Related Experiment Video

Updated: Jul 15, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Genomic evolution of Hox gene clusters.

Derek Lemons1, William McGinnis

  • 1Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA.

Science (New York, N.Y.)
|September 30, 2006
PubMed
Summary

Hox genes control animal body axis development. Recent studies reveal fragmented Hox gene clusters correlate with evolutionary morphological changes, challenging traditional colinear arrangement models.

Area of Science:

  • Developmental Biology
  • Evolutionary Genetics
  • Genomics

Background:

  • Hox genes are crucial for establishing the main body axis in metazoans.
  • Traditionally, Hox genes were thought to be organized in contiguous chromosomal clusters with colinear expression patterns.
  • Recent findings challenge this model, indicating variability in Hox gene cluster organization.

Purpose of the Study:

  • To explore the implications of non-colinear Hox gene cluster organization in animal evolution.
  • To investigate the role of noncoding RNAs within Hox gene clusters.

Main Methods:

  • Comparative genomics analysis of Hox gene cluster organization across diverse animal taxa.
  • Bioinformatic identification and characterization of noncoding RNAs within Hox gene clusters.

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  • Review of existing literature on the functional roles of these noncoding RNAs.
  • Main Results:

    • Hox gene clusters are frequently fragmented, reduced, or expanded in various animal groups.
    • These genomic alterations in Hox clusters correlate with significant evolutionary changes in morphology.
    • Hox gene clusters harbor diverse noncoding RNAs, including regulatory transcripts and microRNAs, with emerging evidence for their developmental roles.

    Conclusions:

    • The organization of Hox gene clusters is more dynamic than previously assumed.
    • Variations in Hox gene cluster structure are linked to morphological evolution.
    • Noncoding RNAs within Hox clusters represent a significant, yet understudied, layer of developmental regulation.