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Related Experiment Videos

White matter changes in elderly people: MR-pathologic correlations.

Eiji Matsusue1, Shuji Sugihara, Shinya Fujii

  • 1Division of Radiology, Department of Pathophysiological and Therapeutic Science, Tottori University, Japan. matsusue@grape.med.tottori-u.ac.jp

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
|September 30, 2006
PubMed
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Magnetic resonance imaging (MRI) findings in elderly white matter lesions correlate with histology. Understanding these pathological features aids in interpreting MRI scans of age-related brain changes.

Area of Science:

  • Neurology
  • Radiology
  • Pathology

Background:

  • White matter lesions are common in the elderly and have characteristic appearances on Magnetic Resonance (MR) imaging.
  • Histologic examination provides crucial insights into the pathological basis of these imaging findings.

Purpose of the Study:

  • To correlate the histopathological features of white matter lesions with their corresponding MR imaging characteristics.
  • To enhance the understanding of incidental findings in the white matter of elderly individuals.

Main Methods:

  • Correlation of MR imaging findings with histologic examination of brain tissue.
  • Detailed description of specific white matter abnormalities observed on MR imaging, such as dilated perivascular spaces, lacunar infarcts, and periventricular hyperintensities.

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Main Results:

  • Dilated perivascular spaces (<3 mm) with sharp margins are observed in the subcortical white matter.
  • Old lacunar infarcts (>3 mm) are irregularly shaped with associated myelin pallor and gliosis.
  • Periventricular and deep white matter hyperintensities reflect myelin pallor, dilated perivascular spaces, and gliosis, with Binswanger's disease showing diffuse changes.

Conclusions:

  • Knowledge of the pathological underpinnings of white matter changes is essential for accurate interpretation of MR imaging.
  • The study provides a bridge between macroscopic imaging and microscopic pathology in age-related white matter alterations.