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Updated: Jul 19, 2026

Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
[A case of Listeria monocytogenes meningitis in an immunocompetent infant]
G Pattarino1, S Arrigoni, R Grazioli
1Clinica Pediatrica, Ospedale L. Sacco, Via Breguzzo 5, 20148 Milan, Italy. gpattarino@hotmail.com
Abstract:
Listeria Monocytogenes meningitis is a rare affection after the neonatal period, but in immunocompromised patients. Listeria Monocytogenes is a Gram-positive, facultative intracellular bacterium frequently causing infection in pregnant women, in patients with cell-mediated immunity deficit and in the early and late stages of life. We present a case of Listeria Monocytogenes meningitis in an immunocompetent nomad 8-month-child, preceded by gastroenteritis. Although gastrointestinal symptoms may be due to intestinal infection by Listeria, the concomitant presence of other bacteric or viral enteric pathogens may have promoted bacterium intestinal translocation and generated disseminated disease. The main transmission route of infection after the neonatal period is ingestion of contaminated food. A diet history was taken after isolation of the bacterium in liquor and showed that the child was an eater of undercooked hot-dogs. Despite the frequency of clinical complication in such affection, the outcome in this patient was a complete recovery. Although the infection is extremely infrequent in healthy children, physicians should always consider Listeria as a possible etiologic agent of meningitis in pediatric patients, regardless of their age or immunological status, especially in patients living in precarious sanitary conditions, where weaning times and conditions are not respected and a suitable food cooking is not assured.
Insights
Listeria Monocytogenes meningitis is rare in healthy children but can occur. This case highlights the importance of considering this bacterium in pediatric meningitis, especially with gastrointestinal symptoms.
Area of Science:
- Infectious Diseases
- Bacteriology
- Pediatrics
Background:
- Listeria Monocytogenes meningitis is uncommon outside the neonatal period, typically affecting immunocompromised individuals.
- Risk factors include pregnancy, cell-mediated immunity deficits, and extremes of age.
- The primary transmission route post-neonatal period is through contaminated food ingestion.
Observation:
- A case of Listeria Monocytogenes meningitis in an 8-month-old immunocompetent child is presented.
- The meningitis was preceded by gastroenteritis, suggesting potential intestinal translocation of the bacterium.
- The child consumed undercooked hot-dogs, a likely source of Listeria Monocytogenes infection.
Findings:
- Listeria Monocytogenes was isolated from the cerebrospinal fluid, confirming bacterial meningitis.
- Despite the severity of Listeria Monocytogenes meningitis, the child experienced a complete recovery.
- This case underscores the possibility of Listeria Monocytogenes infection in healthy children.
Implications:
- Pediatricians should consider Listeria Monocytogenes in the differential diagnosis of meningitis in children, irrespective of immune status.
- Particular vigilance is warranted in populations with precarious sanitary conditions and inadequate food preparation practices.
- Early recognition and appropriate treatment are crucial for favorable outcomes in pediatric Listeria Monocytogenes meningitis.
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