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Decrease of total antioxidant capacity during coronary artery bypass surgery.

Alper Sami Kunt1, Sahbettin Selek, Hakim Celik

  • 1Department of Cardiovascular Surgery, Harran University, Research Hospital, TR-63100 Sanliurfa, Turkey. dralper@msn.com

The Mount Sinai Journal of Medicine, New York
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Summary

Coronary artery bypass grafting (CABG) surgery causes significant oxidative stress, decreasing the body's antioxidant capacity. This oxidative stress is linked to longer surgery times and reduced heart function, suggesting potential benefits from antioxidant supplementation.

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Area of Science:

  • Cardiovascular Surgery
  • Oxidative Stress Research
  • Biochemistry

Background:

  • Cardiac surgery, specifically coronary artery bypass grafting (CABG), is known to induce oxidative stress.
  • This oxidative stress can potentially impair cardiac function post-surgery.

Purpose of the Study:

  • To quantify the changes in oxidative and antioxidative status in patients undergoing CABG.
  • To investigate the relationship between oxidative stress markers and surgical parameters.

Main Methods:

  • Studied 79 patients undergoing CABG, with and without cardiopulmonary bypass (CPB).
  • Measured total peroxide (TP) and oxidative stress index (OSI) for oxidative status.
  • Assessed total antioxidant capacity (TAC) for antioxidative status.
  • Collected blood samples pre-operatively, intra-operatively, and post-operatively.

Main Results:

  • TP and OSI levels significantly increased, while TAC levels progressively decreased throughout the surgery.
  • Found negative correlations between TAC and aortic cross-clamping/anastomosis times.
  • Observed a positive correlation between TAC and ejection fraction.

Conclusions:

  • CABG surgery leads to a significant increase in oxidative stress and a decrease in antioxidant capacity.
  • Surgical duration (CPB, anastomosis time) and lower ejection fraction exacerbate oxidative stress.
  • Antioxidant vitamin supplementation (e.g., vitamins C and E) may be beneficial for CABG patients.