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Short mucin 6 alleles are associated with H pylori infection

Thai V Nguyen1, Marcel Janssen, Paulien Gritters

  • 1Department of Gastroenterology, Can Tho University of Medicine and Pharmacy, Viet Nam.

World Journal of Gastroenterology
|September 30, 2006
PubMed
Abstract

Insights

Short mucin 6 (MUC6) alleles are linked to Helicobacter pylori infection. This study found a higher prevalence of H. pylori in patients with shorter MUC6 gene variants.

Area of Science:

  • Genetics
  • Microbiology
  • Gastroenterology

Background:

  • Mucin 6 (MUC6) is a key component of the gastric mucus layer.
  • Variations in MUC6 variable number tandem repeat (VNTR) length may influence susceptibility to infections.
  • Helicobacter pylori (H. pylori) is a common pathogen associated with various gastrointestinal diseases.

Purpose of the Study:

  • To examine the association between MUC6 VNTR allele lengths and H. pylori infection status.
  • To determine if specific MUC6 genotypes correlate with H. pylori prevalence.

Main Methods:

  • Collected blood samples from 160 patients undergoing upper gastrointestinal endoscopy.
  • Isolated DNA and analyzed MUC6 VNTR fragment lengths using restriction enzyme digestion (Pvu II) and Southern blotting.
  • Diagnosed H. pylori infection via the (14)C urea breath test and classified MUC6 genotypes (LL, LS, SS).

Main Results:

  • H. pylori infection was present in 58% of the study population.
  • Prevalence of H. pylori infection varied significantly across MUC6 genotypes: 43% in LL, 57% in LS, and 76% in SS.
  • A statistically significant association (P = 0.003) was observed between MUC6 genotype and H. pylori infection.

Conclusions:

  • Shorter MUC6 alleles are significantly associated with an increased risk of H. pylori infection.
  • MUC6 VNTR length may play a role in modulating host susceptibility to H. pylori.

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