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An immunological study of Lyme disease
1Laboratory for Infectious Disease Research, Charles University Paediatric Faculty, Prague.
Czechoslovak Medicine
|January 1, 1990
Summary
This study investigated autoimmune mechanisms in Lyme disease neuroborreliosis. Results indicate a significant role for autoimmune reactions in central and peripheral nervous system involvement, suggesting immunomodulating therapy as a potential treatment complement.
Area of Science:
- Neuroimmunology
- Infectious Diseases
- Neurology
Background:
- Lyme disease can affect the central and peripheral nervous systems.
- The role of autoimmune mechanisms in Lyme neuroborreliosis requires further investigation.
Purpose of the Study:
- To evaluate the participation of autoimmune mechanisms in Lyme disease affecting the nervous system.
- To assess cell hypersensitivity to myelin antigens in patients with Lyme neuroborreliosis.
Main Methods:
- Tested 84 patients with serologically diagnosed Lyme disease and nervous system involvement.
- Assessed cell hypersensitivity using the macrophage slowing factor assay on a cytopherometer.
- Measured lymphocyte response to encephalitogenic basic protein and peripheral myelin antigens.
Main Results:
- Evidence suggests autoimmune reactions play a significant role in Lyme neuroborreliosis.
- Lyme disease shows a prominent position regarding autoimmune reactions compared to other neuroinfections.
- No statistically significant changes were observed in total and active T lymphocytes.
Conclusions:
- Autoimmune mechanisms are implicated in the pathogenesis of Lyme disease affecting the nervous system.
- Disordered immunoregulating mechanisms may explain the observed autoimmune responses.
- Immunomodulating therapy could be a valuable addition to antibiotic treatment for Lyme neuroborreliosis.