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iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

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Related Experiment Video

Updated: Jul 19, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats.

Raymond D Lund¹, Shaomei Wang, Irina Klimanskaya

¹Moran Eye Center, University of Utah Health Science Center, Salt Lake City, Utah, USA.

Cloning and Stem Cells

|October 3, 2006

Summary

Human embryonic stem cell-derived retinal pigment epithelium (RPE) successfully restored photoreceptor function in a rat model of macular degeneration. This advancement offers a promising source for treating retinal degenerative diseases.

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Last Updated: Jul 19, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

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Published on: January 22, 2018

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice

Sub-Retinal Delivery of Human Embryonic Stem Cell Derived Photoreceptor Progenitors in rd10 Mice

Published on: October 6, 2023

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

Area of Science:

Regenerative Medicine
Ophthalmology
Stem Cell Biology

Background:

Embryonic stem cells offer a reproducible source for replacement tissues.
Retinal pigment epithelium (RPE) transplantation is a potential therapy for retinal degenerative diseases like macular degeneration.

Purpose of the Study:

To demonstrate the reproducible generation of human embryonic stem cell-derived RPE (hES-RPE).
To evaluate the therapeutic potential of hES-RPE in an animal model of retinal disease.

Main Methods:

Generated RPE from 18 different human embryonic stem cell (hES) lines.
Tested hES-RPE derived from NIH-approved H9 hES cells in Royal College of Surgeons (RCS) rats with inherited retinal degeneration.
Assessed photoreceptor rescue and visual performance in treated rats.

Main Results:

Established 67 passageable hES-RPE cultures.
Achieved 100% improvement in visual performance in treated RCS rats compared to controls.
Demonstrated significant photoreceptor rescue without adverse pathology.

Conclusions:

Reproducible generation of functional hES-RPE is achievable.
hES-RPE transplantation shows significant therapeutic potential for retinal degenerative diseases.
Somatic cell nuclear transfer (SCNT) and HLA-matched hES-RPE banks could reduce immunosuppression needs.