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Updated: Jul 19, 2026
08:47
Monitoring eIF4F Assembly by Measuring eIF4E-eIF4G Interaction in Live Cells
Published on: May 1, 2020
Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer
Sheng Zhou1, Guo-Ping Wang, Cong Liu
1Department of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. zhou71@163.com
BMC Cancer
|October 3, 2006
Summary
Overexpression of eukaryotic translation initiation factor 4E (eIF4E) in breast cancer correlates with increased angiogenesis and poorer patient survival. eIF4E is an independent prognostic factor, suggesting its potential as a therapeutic target.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- Eukaryotic translation initiation factor 4E (eIF4E) overexpression is implicated in breast cancer malignancy.
- This study explores the link between eIF4E, angiogenesis, and patient prognosis in breast cancer.
Purpose of the Study:
- To investigate the correlation between eIF4E expression and angiogenesis markers (VEGF, IL-8, MVD) in breast cancer.
- To determine the prognostic significance of eIF4E in breast cancer patients.
Main Methods:
- Immunohistochemical analysis of eIF4E, VEGF, IL-8, and CD105 in 122 breast cancer tissues.
- Assessment of microvessel density (MVD) using CD105.
- Correlation analysis and multivariate Cox regression.
Main Results:
- eIF4E expression significantly correlates with histological grade, VEGF, IL-8, and MVD.
- Higher eIF4E levels are associated with worse overall and disease-free survival.
- eIF4E is an independent prognostic factor for breast cancer, alongside stage and MVD.
Conclusions:
- Elevated eIF4E expression is linked to angiogenesis and vascular invasion in breast cancer.
- eIF4E may serve as a predictive biomarker for unfavorable outcomes.
- eIF4E represents a potential therapeutic target for breast cancer treatment.
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