Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Defective antigen-presenting cell function in human neonates.

Paula A Velilla1, Maria T Rugeles, Claire A Chougnet

  • 1Group Immunovirology, Biogenesis Corporation, University of Antioquia, Medellín, A.A. 1226 Colombia.

Clinical Immunology (Orlando, Fla.)
|October 3, 2006
PubMed
Summary

Neonatal antigen-presenting cells (APCs) show functional alterations, contributing to infant immune system immaturity and increased infection susceptibility. Understanding these APC defects is crucial for improving infant health outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vitamin D boosts HIV-1 resistance in female genital epithelial cells by enhancing antiviral cathelicidin expression.

Frontiers in immunology·2026
Same author

Decoding NK Cell Subset Dysregulation in SARS-CoV-2 Infection: Phenotypic, Functional, and Transcriptomic Insights Into COVID-19 Pathogenesis.

Scandinavian journal of immunology·2026
Same author

Re: Female Reproductive Tract-on-a-Chip for Selecting Sperm with Ultra-low DNA Fragmentation Index.

European urology·2026
Same author

Decidual CD4 Effector Memory and Resident Memory T Cells Respond to Cord Blood Allo-Antigens.

American journal of reproductive immunology (New York, N.Y. : 1989)·2026
Same author

Diffuse neuroinflammation and immature neuron loss in fetal Rhesus macaques after short-term intrauterine infection.

Journal of neuroinflammation·2026
Same author

Maternal antibiotic exposure-mediated alterations in basal, and allergen-induced lung function are associated with altered recruitment of eosinophils to the developing lung.

Frontiers in immunology·2026

Area of Science:

  • Immunology
  • Neonatal immunology
  • Cellular immunology

Background:

  • Neonatal immune system immaturity contributes to high infant morbidity and mortality from infections.
  • Functional impairment of neonatal T cells is a commonly cited cause of this immaturity.
  • Emerging evidence points to functional alterations in neonatal antigen-presenting cells (APCs) as a significant factor.

Purpose of the Study:

  • To review the current understanding of antigen-presenting cell (APC) functionality in newborns and early childhood.
  • To explore the potential mechanisms underlying neonatal APC alterations.
  • To highlight the need for further research into the functional capacity of the neonatal immune system.

Main Methods:

  • Review of existing scientific literature on neonatal APC function.

Related Experiment Videos

  • Analysis of studies comparing neonatal and adult APC characteristics.
  • Discussion of factors influencing neonatal APC behavior.

    • Main Results:

    • Neonatal APCs exhibit markers of immaturity compared to adult APCs.
    • Neonatal APCs produce lower levels of cytokines.
    • Potential contributing factors include intrinsic immaturity, impaired APC-T cell interactions, and regulatory T cell inhibition.

    Conclusions:

    • Neonatal APCs display functional deficits that can impact adaptive T cell responses.
    • Multiple mechanisms likely contribute to these APC alterations.
    • Further research is necessary to elucidate the precise roles of these mechanisms and understand the neonatal immune system's capabilities.