Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Intrauterine Drug Delivery Systems

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...

Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

Oral Drug Delivery Systems: Introduction

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CRESTONE: A Phase II Study of the Efficacy and Safety of the HER3 Monoclonal Antibody, Seribantumab, in Solid Tumors With Neuregulin-1 (<i>NRG1</i>) Fusions.

JCO precision oncology·2025

Same author

Unraveling the complexity of bladder-centric chronic pain by intravesical contrast enhanced MRI.

Continence (Amsterdam, Netherlands)·2025

Same author

Targeting tumor-associated microbiome: A new aspect of modulating tumor microenvironment for cancer therapy.

Advanced drug delivery reviews·2025

Same author

Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer.

The Journal of experimental medicine·2024

Same author

Correction: Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options.

Drugs & aging·2024

Same author

Dynamic Covalent Hydrogel as a Single-Dose Vaccine Adjuvant for Sustained Antigen Release and Significantly Elevated Humoral Immunity.

Advanced healthcare materials·2024

Search research articles

Related Experiment Video

Updated: Jul 19, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Local drug delivery to bladder using technology innovations.

Pradeep Tyagi¹, Shachi Tyagi, Jonathan Kaufman

¹Department of Urology, University of Pittsburgh School of Medicine, Kaufmann Medical Building, Suite 700, 3471 Fifth Avenue, Pittsburgh, PA 15213-3221, USA. prtst2@pitt.edu

The Urologic Clinics of North America

|October 3, 2006

Summary

Intravesical drug delivery via catheter optimizes bladder treatment and minimizes side effects. Recent innovations address limitations in current intravesical therapy options for conditions like neurogenic bladder.

More Related Videos

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Related Experiment Videos

Last Updated: Jul 19, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models

Published on: August 9, 2012

Area of Science:

Urology
Pharmacology
Biomedical Engineering

Background:

Intravesical drug delivery involves administering medications directly into the bladder through a urethral catheter.
This method enhances drug concentration at the target site while reducing systemic absorption and toxicity.
It is increasingly used for conditions such as neurogenic bladder and detrusor overactivity, often alongside oral treatments.

Purpose of the Study:

To review the limitations of existing intravesical drug delivery systems.
To provide an overview of recent technological advancements aimed at improving intravesical therapy.

Main Methods:

Literature review and analysis of current intravesical delivery technologies.
Discussion of technological innovations and their potential impact on drug delivery efficacy and safety.

Main Results:

Current intravesical delivery methods have specific shortcomings that impact treatment effectiveness.
New technologies offer promising solutions to overcome these existing drawbacks.
Minimal systemic absorption leads to a favorable safety profile for intravesical drug administration.

Conclusions:

Intravesical drug delivery is an effective strategy for bladder conditions with low systemic toxicity.
Technological innovations are crucial for advancing intravesical therapy and addressing current limitations.
Further research into novel delivery systems will enhance treatment outcomes for patients.