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Interaction of substance P, compound 48/80 and mastoparan with the alpha-subunit C-terminus of G protein
M Mousli1, C Bronner, J Bockaert
1Laboratoire de Neuroimmunopharmacologie, Université Louis Pasteur, Strasbourg I, France.
Immunology Letters
|September 1, 1990
Abstract:
Pretreatment of purified calf brain G proteins with activated pertussis toxin or antibodies raised against the C-terminus of their alpha subunits prevented the increase in GTPase activity induced by substance P, compound 48/80 and mastoparan. These results suggest that these mast cell secretagogues activate G proteins directly via an interaction with the C-terminus of alpha subunits of G proteins by mimicking the agonist-liganded receptors.