5-HT(1B) receptors play a prominent role in the proliferation of T-lymphocytes
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Updated: Jul 19, 2026

Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
Jun Yin1, Ross H Albert, Anna P Tretiakova
1Department of Biochemistry and Molecular Biology at Drexel University College of Medicine, Philadelphia, PA, USA.
Abstract:
Serotonin plays a role in T cell activation, but there is no clear consensus of which of the 14 serotonergic receptors control this activations pathway. We have used a broad range of serotonergic receptor antagonists to define the functional involvement of these receptors governing the proliferation of primary T cells as well as in T cell lines. Our data shows that antagonism of the 5-HT(1B) receptor inhibits the proliferation of both human and murine primary helper T cells and of human helper T cell lines. As a whole, our data suggest that other serotonergic receptors may contribute to the proliferative signals, but the 5-HT(1B) receptor plays the most dominant role.
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