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Related Experiment Videos

Polypoidal choroidal vasculopathy with choroidal vascular hyperpermeability.

Manabu Sasahara1, Akitaka Tsujikawa, Kunihiro Musashi

  • 1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. sasahara@kuhp.kyoto-u.ac.jp

American Journal of Ophthalmology
|October 3, 2006
PubMed
Summary

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Multifocal choroidal hyperfluorescence, a sign of choroidal vascular hyperpermeability, is more common in polypoidal choroidal vasculopathy (PCV) than in age-related macular degeneration (AMD). This finding suggests hyperpermeability may be a risk factor for PCV.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Vascular Biology

Background:

  • Polypoidal choroidal vasculopathy (PCV) is a subtype of exudative age-related macular degeneration (AMD).
  • Choroidal vascular hyperpermeability is a known characteristic of central serous chorioretinopathy (CSC).

Purpose of the Study:

  • To investigate the incidence and clinical features of PCV associated with choroidal vascular hyperpermeability.
  • To compare the occurrence of choroidal vascular hyperpermeability in PCV versus exudative AMD.

Main Methods:

  • Retrospective observational case series.
  • Review of medical records for 122 eyes with PCV and 106 eyes with exudative AMD.
  • Indocyanine green (ICG) angiography to evaluate choroidal vascular hyperpermeability, characterized by multifocal patchy hyperfluorescence.

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Main Results:

  • Multifocal choroidal hyperfluorescence was observed in 9.8% of PCV eyes versus 1.9% of exudative AMD eyes (P = .013).
  • PCV eyes with hyperfluorescence showed choroidal filling delay (58%) and venous dilation (100%).
  • A history of CSC was noted in 33% of these PCV patients, with bilateral findings in 90%.

Conclusions:

  • Multifocal choroidal hyperfluorescence on ICG angiography is significantly more frequent in PCV than in exudative AMD.
  • Choroidal vascular hyperpermeability may be a contributing risk factor for the development of PCV.