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Updated: Jul 19, 2026
Puncture-Induced Iris Neovascularization as a Mouse Model of Rubeosis Iridis
Published on: March 8, 2018
Rubeosis and anterior segment ischemia associated with systemic cryoglobulinemia
David G Telander1, Gary N Holland, Martin B Wax
1Ocular Inflammatory Disease Center, Jules Stein Eye Institute, and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Purpose:
To report two cases of iris neovascularization associated with systemic cryoglobulinemia.
Design:
Retrospective case report.
Methods:
Patient chart review and review of literature.
Results:
Two patients with iris neovascularization in the absence of retinal ischemia were subsequently found to have systemic cryoglobulinemia. Successful treatment of one patient's underlying lymphoma led to stabilization and resolution of neovascularization.
Conclusions:
Systemic cryoglobulinemia may be associated with anterior segment ischemia and neovascularization, and should be considered in the differential diagnosis of iris neovascularization in the absence of apparent retinal ischemia.
