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Updated: Jul 19, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Bilateral diffuse melanocytic proliferation associated with ovarian carcinoma and metastatic malignant amelanotic
Hon-Vu Q Duong1, Ian W McLean, Donald E Beahm
1Department of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA. Tenthsfg@msn.com
Purpose:
To report a case of metastatic malignant amelanotic melanoma to the skin from a patient diagnosed with bilateral diffuse uveal melanocytic proliferation (BDUMP). This dermatological finding is a unique phenomenon associated with BDUMP.
Design:
Retrospective case report.
Methods:
We studied the case of a 66-year-old Caucasian woman with gradual onset of blurred vision in her right eye followed by her left eye. She had previously been diagnosed with ovarian carcinoma, and findings of funduscopic examinations were consistent with BDUMP. Metastatic examination revealed no evidence of liver involvement. Clinical and histopathological examinations of both enucleated eyes were consistent with BDUMP.
Results:
The hematoxylin and eosin, S-100, and HMB-45 stains were consistent with metastatic malignant amelanotic melanoma to the skin.
Conclusions:
Although believed to have a low potential for metastasis, patients should be monitored and evaluated regularly to detect any new lesions not associated with their primary inciting carcinoma.
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