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Updated: Jul 19, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
Published on: October 25, 2018
Anti-beta2 glycoprotein 1 and the anti-phospholipid syndrome
Pearse A Keane1, Kesavan Ravikumar, Susan I O'shea
1Department of Ophthalmology, Cork University Hospital, Cork, Ireland. pearsek@iol.ie
Purpose:
To describe a patient who presented with bilateral retinal vascular occlusion and the use of anti-beta2 glycoprotein 1 (GPI) antibody testing in the diagnosis of antiphospholipid syndrome.
Design:
Observational case report.
Methods:
Hematological investigations were performed on a 49-year-old man who presented with rapid onset of bilateral severe central retinal vein occlusion.
Results:
Lupus anticoagulant and anticardiolipin antibody testing was negative. Markedly raised titers of anti-beta2 GPI antibodies were detected on two separate occasions.
Conclusions:
The raised titers of anti-beta2 GPI antibodies were considered to strongly suggest an underlying diagnosis of the antiphospholipid syndrome.
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