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Related Experiment Videos

Plasticity.

Randolph J Nudo1

  • 1University of Kansas Medical Center, Landon Center on Aging and Department of Molecular and Integrative Physiology, Kansas City, Kansas 66160, USA. RNUDO@kumc.edu

Neurorx : the Journal of the American Society for Experimental Neurotherapeutics
|October 3, 2006
PubMed
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Central nervous system plasticity allows the brain to change after injury. Understanding this neuroplasticity is key to developing better therapies for neurological disorders like stroke.

Area of Science:

  • Neuroscience
  • Neurobiology
  • Rehabilitation Science

Background:

  • The central nervous system (CNS) exhibits lifelong plasticity, its ability to change structure and function.
  • CNS injury, particularly focal injury, strongly triggers neuroplasticity.
  • Post-injury plasticity involves complex, time-dependent changes in the brain, which can be adaptive or maladaptive.

Purpose of the Study:

  • To review recent findings on the time course of CNS plasticity after cortical injury.
  • To explore how modulating plasticity can lead to improved therapeutic interventions for neurological disorders.
  • To discuss the implications of these findings for neurorehabilitation.

Main Methods:

  • Review of recent results from animal models of CNS injury and recovery.

Related Experiment Videos

  • Analysis of neurophysiological and neuroanatomical changes following focal cortical injury.
  • Examination of the role of behavioral training and adjuvant therapies in promoting adaptive plasticity.

    • Main Results:

    • Cortical injury induces widespread neuroplastic changes in both ipsilesional and contralesional areas.
    • The cascade of these changes is complex and time-dependent.
    • Behavioral training is a significant factor in promoting adaptive plasticity post-injury.

    Conclusions:

    • Understanding the temporal dynamics of post-injury plasticity is crucial for effective neurorehabilitation.
    • Behavioral training provides a neuroscientific basis for physical therapies after CNS injury.
    • Adjuvant therapies, including pharmacological agents and electrical stimulation, may enhance the efficacy of behavioral interventions.