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Updated: Jul 19, 2026

Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis
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Published on: July 16, 2008

Prion protein helix1 promotes aggregation but is not converted into beta-sheet

Jens Watzlawik1, Lukasz Skora, Dieter Frense

  • 1Prion and Dementia Research Unit, Institute of Neuropathology, University of Goettingen, 37075 Goettingen, Germany.

The Journal of Biological Chemistry
|October 3, 2006
PubMed
Summary

Prion diseases involve prion protein (PrP(C)) aggregation. This study shows helix1 is crucial for aggregation but does not convert to beta-sheet, challenging existing prion disease models.

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