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Treatment for obstructive sleep apnoea: effect on peripheral nerve function.

Rainer Dziewas1, Matthias Schilling, Philipp Engel

  • 1Department of Neurology, University Hospital of Münster, Albert-Schweitzer-Strasse 33, 48129 Münster, Germany. dziewas@uni-muenster.de

Journal of Neurology, Neurosurgery, and Psychiatry
|October 3, 2006
PubMed
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Obstructive sleep apnoea (OSA) is linked to peripheral nerve damage. Treating OSA improves nerve function, with compliance being key to recovery.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Peripheral Nerve Disorders

Background:

  • Obstructive sleep apnoea (OSA) is increasingly associated with peripheral nerve damage.
  • A case-control study investigated this link and the effect of OSA treatment on nerve function.

Purpose of the Study:

  • To determine if OSA is an independent risk factor for peripheral sensory nerve axonal dysfunction.
  • To assess the impact of OSA treatment on peripheral nerve function.

Main Methods:

  • A case-control study compared 23 OSA patients with 23 controls, measuring sural nerve sensory nerve action potential (SNAP) amplitudes.
  • Nerve conduction studies were repeated after 6 months of OSA treatment, with compliance evaluated.

Main Results:

Related Experiment Videos

  • OSA patients exhibited significantly lower sural SNAP amplitudes compared to controls.
  • Age and Apnoea-Hypopnea Index (AHI) were inversely related to SNAP amplitude.
  • Sural SNAP amplitudes increased significantly after treatment, with compliance strongly correlating with improvement.

Conclusions:

  • Obstructive sleep apnoea is an independent risk factor for peripheral sensory nerve axonal dysfunction.
  • Impaired nerve function due to OSA is at least partially reversible with treatment.