Related Experiment Video
Updated: Jul 19, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
Published on: May 4, 2021
Parental smoking increases exhaled nitric oxide in young children
P J Franklin1, S Turner, R Mutch
1School of Paediatrics and Child Health, University of Western Australia, GPO Box D184, Perth 6840 Western Australia. peterf@sph.uwa.edu.au
Abstract:
The present study investigated the association between reported parental smoking and exhaled nitric oxide fraction (F(eNO)) in young children. In total, 78 children (24 females, mean age 51.3 weeks) were recruited. Fourteen lived with one smoking parent and eight with two smoking parents. F(eNO) was measured using the modified single-breath technique. Mean+/-sd F(eNO) levels were 33.0+/-18.9, 38.3+/-15.0 and 48.3+/-14.7 ppb for children with no, one and two smoking parents, respectively. There was a significant linear trend across the groups and, after controlling for other relevant factors, a significant difference between the groups. In the present study, exposure to environmental tobacco smoke was associated with increased exhaled nitric oxide fraction in young children. Furthermore, there was evidence of a dose-response relationship between childhood exhaled nitric oxide fraction and the number of smoking parents.
Related Concept Videos
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Pulmonary Cycle: Exhalation
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Breathing
Chronic Obstructive Pulmonary Disease I: Introduction