Related Experiment Video

Updated: Jul 19, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

Modeling future changes to the meningococcal serogroup C conjugate (MCC) vaccine program in England and Wales

Caroline L Trotter1, W John Edmunds, Mary E Ramsay

  • 1Immunisation Department, Health Protection Agency Centre for Infections, London, UK. caroline_trotter@yahoo.co.uk

Human Vaccines
|October 3, 2006
PubMed

Insights

The UK meningococcal serogroup C conjugate (MCC) vaccine program effectively controls disease. Mathematical modeling suggests a booster dose could enhance protection and optimize the infant immunization schedule.

Area of Science:

  • Immunology
  • Epidemiology
  • Mathematical Modeling

Background:

  • The UK meningococcal serogroup C conjugate (MCC) vaccine program has significantly reduced serogroup C disease incidence.
  • Current infant immunization schedules provide short-term protection, potentially leaving children vulnerable later.

Purpose of the Study:

  • To predict the future epidemiology of serogroup C disease.
  • To evaluate the impact of altering the MCC immunization schedule on disease control.

Main Methods:

  • Utilized a mathematical model to simulate serogroup C disease spread.
  • Assessed disease incidence with and without proposed changes to the vaccination schedule.

Main Results:

  • Minimal serogroup C disease cases are predicted in the near future due to sustained herd immunity.
  • Introducing a booster dose is projected to increase the overall effectiveness of the MCC program.

Conclusions:

  • While herd immunity currently offers protection, a booster dose can further strengthen the MCC program's impact.
  • Reducing infant doses may improve cost-effectiveness and accommodate additional vaccines in the childhood immunization schedule.

More Related Videos

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes13:53

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Published on: December 19, 2020

Experimental Human Pneumococcal Carriage07:47

Experimental Human Pneumococcal Carriage

Published on: February 15, 2013

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Vaccinations01:51

Vaccinations

Overview
Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Vaccines01:21

Vaccines

Vaccines are among the most effective tools in preventive medicine, designed to prepare the immune system to recognize and combat infectious agents. By introducing antigens—substances that the immune system identifies as foreign—vaccines stimulate an adaptive immune response that leads to immunological memory. This immunological memory enables the body to mount a faster and more effective response upon future exposures to the actual pathogen.Vaccines can be categorized based on the type of...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...