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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

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Related Experiment Video

Updated: Jul 19, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Papillated Bowen disease, a distinct variant.

Joannie D Sun1, Ronald J Barr

  • 1Dermatopathology Laboratory, University of California, Irvine 101 The City Drive South, Building 52, Orange, CA 92868, USA.

The American Journal of Dermatopathology
|October 3, 2006
PubMed
Summary

This study describes a distinct papillated variant of Bowen disease, a skin cancer. Human papillomavirus (HPV) DNA was not detected in these lesions using standard methods, suggesting a unique etiology for this variant.

Related Experiment Videos

Last Updated: Jul 19, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Area of Science:

  • Dermatology
  • Oncology
  • Virology

Background:

  • Bowen disease, a form of squamous cell carcinoma in situ, typically presents as a scaly plaque.
  • A rare clinicopathologic variant, papillated Bowen disease, exhibits distinct exophytic and endophytic growth patterns.
  • Histologically, this variant shows koilocytic changes suggestive of human papillomavirus (HPV) infection.

Purpose of the Study:

  • To evaluate the clinicopathologic features of papillated Bowen disease.
  • To investigate the association of human papillomavirus (HPV) with this specific variant of Bowen disease.

Main Methods:

  • Twenty-six patients with papillated Bowen disease were analyzed.
  • Lesion locations, including head and neck, trunk, and extremities, were recorded.
  • In situ hybridization was used to screen for HPV DNA in lesion specimens.

Main Results:

  • The study evaluated 26 patients (15 males, 11 females; age 33-87).
  • Lesions were most commonly found on the head and neck (54%).
  • HPV DNA from common oncogenic types was not detected in any specimens.

Conclusions:

  • Papillated Bowen disease presents a unique clinicopathologic entity.
  • The absence of detectable HPV DNA suggests that common HPV types may not be implicated in this variant.
  • Further investigation with more sensitive methods is warranted to explore potential HPV involvement.