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Related Experiment Videos

Pleomorphic CD8+ small/medium size cutaneous T-cell lymphoma.

Z Khamaysi1, Y Ben-Arieh, R Epelbaum

  • 1Department of Dermatology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel.

The American Journal of Dermatopathology
|October 3, 2006
PubMed
Summary
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This study details a rare cutaneous T-cell lymphoma case. The pleomorphic small/medium-sized T-cell lymphoma presented as a foot nodule and required surgical excision after initial irradiation.

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Pleomorphic small/medium-sized cutaneous T-cell lymphoma (PMC T-cell lymphoma) is a rare variant of cutaneous T-cell lymphoma.
  • It is distinct from mycosis fungoides and Sezary syndrome.
  • The typical immunophenotype is CD3+CD4+CD8-.

Observation:

  • A 55-year-old female presented with a year-and-a-half history of a pruritic, erythematous foot nodule.
  • Histopathology showed a nonepidermotropic lichenoid and patchy dermal infiltrate of small to medium-sized pleomorphic lymphocytes.
  • Immunophenotyping revealed a CD3+CD4+CD8-TIA-1+ phenotype, with negative staining for CD20, CD30, CD56, TdT, and LMP1, and a Ki-67 proliferation index of 5-10%.

Findings:

  • Gene rearrangement studies confirmed a T-cell clone.
  • No extracutaneous involvement was detected through laboratory and imaging workup.

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  • Initial treatment with local irradiation resulted in only partial remission, necessitating surgical excision.

    • Implications:

    • This case expands the understanding of PMC T-cell lymphoma, particularly the CD8- variant.
    • It highlights the importance of thorough histopathological and immunophenotypic analysis for accurate diagnosis.
    • The case underscores the potential need for multimodal treatment approaches in managing this rare lymphoma.