Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Pleomorphic CD8+ small/medium size cutaneous T-cell lymphoma.

Z Khamaysi¹, Y Ben-Arieh, R Epelbaum

¹Department of Dermatology, Rambam Medical Center and the Bruce Rappaport Faculty of Medicine, Technion, Institute of Technology, Haifa, Israel.

The American Journal of Dermatopathology

|October 3, 2006

Summary

This study details a rare cutaneous T-cell lymphoma case. The pleomorphic small/medium-sized T-cell lymphoma presented as a foot nodule and required surgical excision after initial irradiation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantification of metallic artifact on CT associated with titanium pedicle screws.

Frontiers in veterinary science·2024

Same author

Evaluation of combined treatment with Er:YAG laser and long-pulsed Nd:YAG laser for the treatment of recalcitrant warts: A prospective randomized controlled trial.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023

Same author

Nd:YAG 1064-nm laser for residual infantile hemangioma after propranolol treatment.

Scientific reports·2023

Same author

Updated S2 K guidelines for the management of bullous pemphigoid initiated by the European Academy of Dermatology and Venereology (EADV).

Journal of the European Academy of Dermatology and Venereology : JEADV·2022

Same author

Cannabinoid receptor type 2 is upregulated in synovium following joint injury and mediates anti-inflammatory effects in synovial fibroblasts and macrophages.

Osteoarthritis and cartilage·2021

Same author

Response of spring wheat and potato to foliar application of Zn, Mn and EDTA fertilizers on <sup>137</sup>Cs uptake.

Journal of environmental radioactivity·2020

Area of Science:

Dermatopathology
Oncology

Background:

Pleomorphic small/medium-sized cutaneous T-cell lymphoma (PMC T-cell lymphoma) is a rare variant of cutaneous T-cell lymphoma.
It is distinct from mycosis fungoides and Sezary syndrome.
The typical immunophenotype is CD3+CD4+CD8-.

Observation:

A 55-year-old female presented with a year-and-a-half history of a pruritic, erythematous foot nodule.
Histopathology showed a nonepidermotropic lichenoid and patchy dermal infiltrate of small to medium-sized pleomorphic lymphocytes.
Immunophenotyping revealed a CD3+CD4+CD8-TIA-1+ phenotype, with negative staining for CD20, CD30, CD56, TdT, and LMP1, and a Ki-67 proliferation index of 5-10%.

Findings:

Gene rearrangement studies confirmed a T-cell clone.
No extracutaneous involvement was detected through laboratory and imaging workup.

Related Experiment Videos

Initial treatment with local irradiation resulted in only partial remission, necessitating surgical excision.

Implications:

This case expands the understanding of PMC T-cell lymphoma, particularly the CD8- variant.
It highlights the importance of thorough histopathological and immunophenotypic analysis for accurate diagnosis.
The case underscores the potential need for multimodal treatment approaches in managing this rare lymphoma.