Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxygen delivery and outcome.

M A Hayes1

  • 1Department of Anaesthesia and Intensive Care, Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK.

Current Opinion in Anaesthesiology
|October 3, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pathologic fracture healing after femoral limb salvage in a dog.

Australian veterinary journal·2019
Same author

Purified deoxynivalenol or feed restriction reduces mortality in rainbow trout, Oncorhynchus mykiss (Walbaum), with experimental bacterial coldwater disease but biologically relevant concentrations of deoxynivalenol do not impair the growth of Flavobacterium psychrophilum.

Journal of fish diseases·2014
Same author

Phytase properties and locations in tissues of transgenic pigs secreting phytase in the saliva.

Journal of animal science·2014
Same author

Commentary: the role of the toxicologic pathologist in academia.

Veterinary pathology·2014
Same author

Hepatic injury correlates with apoptosis, regeneration, and nitric oxide synthase expression in canine chronic liver disease.

Veterinary pathology·2013
Same author

Facile production of minor metabolites for drug development using a CYP3A shuffled library.

Metabolic engineering·2011
Same journal

The evolution of nonoperating room anesthesia: navigating a new frontier.

Current opinion in anaesthesiology·2026
Same journal

Enhanced recovery pathways for patients with chronic pain: beyond standard protocols - a narrative review.

Current opinion in anaesthesiology·2026
Same journal

Novel technologies and innovations in postoperative follow-up after regional anesthesia.

Current opinion in anaesthesiology·2026
Same journal

Regional anaesthesia and analgesia in surgical patients with chronic preoperative pain: mechanisms, evidence, and clinical implications.

Current opinion in anaesthesiology·2026
Same journal

Retention in pain care and research: a narrative review focused on implanted medical devices.

Current opinion in anaesthesiology·2026
Same journal

Airway ultrasound in patients undergoing head and neck surgery.

Current opinion in anaesthesiology·2026
See all related articles

Optimizing hemodynamics in high-risk surgery may reduce mortality. However, current evidence does not support targeting specific oxygen delivery values in intensive care patients, possibly due to mitochondrial dysfunction.

Area of Science:

  • Critical Care Medicine
  • Surgical Outcomes
  • Hemodynamic Monitoring

Background:

  • Perioperative hemodynamic optimization in high-risk surgical patients is linked to reduced morbidity and mortality.
  • Current evidence lacks support for achieving specific oxygen delivery and consumption values in critically ill patients post-ICU admission.
  • Mitochondrial dysfunction may impair oxygen consumption in sepsis patients, explaining the limited success of therapies aimed at increasing oxygen delivery.

Purpose of the Study:

  • To review the evidence for perioperative hemodynamic optimization in high-risk surgical patients.
  • To discuss the role of mitochondrial dysfunction in sepsis and its impact on oxygen consumption.
  • To highlight the shift towards noninvasive methods for assessing resuscitation adequacy amid debates on pulmonary artery catheterization.

Related Experiment Videos

Main Methods:

  • Literature review of studies on hemodynamic optimization, sepsis, mitochondrial function, and resuscitation monitoring.
  • Analysis of evidence regarding the efficacy of targeting specific oxygen delivery and consumption values.
  • Discussion of the controversy surrounding pulmonary artery catheterization and the rise of noninvasive techniques.

Main Results:

  • Hemodynamic optimization shows potential benefits in high-risk surgical settings.
  • No conclusive evidence supports targeting specific oxygen delivery/consumption values in critically ill patients.
  • Mitochondrial dysfunction is proposed as a mechanism limiting the effectiveness of oxygen delivery-focused therapies in sepsis.
  • Research is increasingly focused on noninvasive methods for resuscitation assessment.

Conclusions:

  • While perioperative hemodynamic optimization may be beneficial, targeting specific oxygen delivery values in the ICU is not currently supported by evidence.
  • Mitochondrial dysfunction presents a significant challenge in sepsis management.
  • The development and evaluation of noninvasive monitoring techniques are crucial for assessing resuscitation adequacy.