Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
Local Anesthetics: Mechanism of Action01:23

Local Anesthetics: Mechanism of Action

Local anesthetics (LAs) block sensory and motor impulses by inhibiting the sodium channels on the nerve cell membranes. This induces temporary loss of sensation, relieving pain in a specific body area.
Local anesthetics are amphiphilic molecules consisting of a hydrophobic aromatic part linked to a hydrophilic group by an ester or amide linkage. They are weak bases and are usually available as salts, which increases their solubility and stability. Once administered, LAs exist in the body either...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Motor Vehicle Accidents: The Family Practitioner's Role in Their Management.

Canadian family physician Medecin de famille canadien·2011
Same author

Children, automobiles, hospitals and governments.

Canadian family physician Medecin de famille canadien·2011
Same author

Enfants, automobiles, hôpitaux et gouvernements.

Canadian family physician Medecin de famille canadien·2011
Same author

Problems and prevention in proctology.

Canadian family physician Medecin de famille canadien·2011
Same author

Observations and predictions of secondary neutrons on Space Shuttle and aircraft.

Advances in space research : the official journal of the Committee on Space Research (COSPAR)·2001
Same author

Clonidine suppresses plasma and cerebrospinal fluid concentrations of TNF-alpha during the perioperative period.

Anesthesia and analgesia·2001

Related Experiment Video

Updated: Jul 19, 2026

Use of a Hanging Weight System for Coronary Artery Occlusion in Mice
08:30

Use of a Hanging Weight System for Coronary Artery Occlusion in Mice

Published on: April 19, 2011

Volatile anesthetic effects on ischemic myocardium.

N Nader-Djalal1, P R Knight

  • 1Department of Anesthesiology, State University of New York at Buffalo, Buffalo, New York, USA. nnaderdj@acsu.buffalo.edu

Current Opinion in Anaesthesiology
|October 3, 2006
PubMed
Summary

New volatile anesthetics offer rapid recovery and potential heart protection, benefiting patients undergoing coronary artery bypass surgery. These agents may improve

More Related Videos

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
08:30

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest

Published on: August 6, 2015

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
08:01

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System

Published on: June 11, 2020

Related Experiment Videos

Last Updated: Jul 19, 2026

Use of a Hanging Weight System for Coronary Artery Occlusion in Mice
08:30

Use of a Hanging Weight System for Coronary Artery Occlusion in Mice

Published on: April 19, 2011

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
08:30

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest

Published on: August 6, 2015

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
08:01

Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System

Published on: June 11, 2020

Area of Science:

  • Anesthesiology
  • Cardiovascular Anesthesia
  • Pharmacology

Background:

  • Volatile anesthetics are crucial for maintaining anesthesia during surgical procedures.
  • Newer generation volatile anesthetic agents exhibit distinct pharmacokinetic profiles.
  • Emerging evidence suggests cardioprotective properties of certain anesthetic agents during ischemia.

Purpose of the Study:

  • To evaluate the clinical implications of rapid onset and offset properties of new volatile anesthetics.
  • To explore the potential benefits of these agents in patients undergoing coronary revascularization.
  • To assess the feasibility of 'fast tracking' patients with these anesthetic agents.

Main Methods:

  • Review of current literature on volatile anesthetic pharmacokinetics and pharmacodynamics.
  • Analysis of clinical evidence regarding recovery times and patient outcomes.
  • Examination of studies investigating myocardial protective effects during ischemic events.

Main Results:

  • Newer volatile anesthetics demonstrate significantly faster onset and offset of action compared to older agents.
  • Rapid recovery facilitates quicker extubation and potential reduction in intensive care unit (ICU) stay.
  • Evidence supports a protective role against myocardial ischemia, reducing perioperative cardiac events.

Conclusions:

  • The rapid action profile of new volatile anesthetics enhances patient recovery and facilitates early mobilization.
  • Cardioprotective effects may translate to improved outcomes in high-risk cardiac surgical patients.
  • These agents present a promising option for 'fast tracking' patients undergoing coronary revascularization, optimizing resource utilization and patient flow.