Related Experiment Video

Updated: Jul 19, 2026

Strategies for Study of Neuroprotection from Cold-preconditioning
16:27

Strategies for Study of Neuroprotection from Cold-preconditioning

Published on: September 2, 2010

Neuroprotection (including hypothermia)

D K Menon1, A C Summors

  • 1Department of Anaesthesiology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. dkm13@wbic.cam.ac.uk

Current Opinion in Anaesthesiology
|October 3, 2006
PubMed

Insights

Neuroprotection research shows promise in areas like inflammation and gene therapy, but clinical success remains limited. This study explores reasons why experimental neuroprotection fails to translate into patient benefits.

Area of Science:

  • Neuroscience
  • Translational Medicine
  • Pharmacology

Background:

  • Over 2000 publications in the past year highlight intense research in neuroprotection.
  • Emerging therapeutic targets include cerebral inflammation, hypothermia, neural transplantation, and gene therapy.

Purpose of the Study:

  • To explore the reasons behind the limited clinical translation of successful experimental neuroprotection strategies.

Main Methods:

  • Literature review and analysis of experimental neuroprotection studies.
  • Comparative analysis of preclinical findings versus clinical trial outcomes.

Main Results:

  • Despite numerous publications, few neuroprotection strategies have achieved clinical success.
  • Significant gap exists between experimental efficacy and patient benefit.

Conclusions:

  • The discrepancy between experimental neuroprotection success and clinical outcomes requires further investigation.
  • Identifying barriers to clinical translation is crucial for advancing neuroprotective therapies.

More Related Videos

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.