Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Strategies to prevent organ failure.

J F FitzGerald1, S H Fox, J M Civetta

  • 1Hartford Hospital, Hartford, CT, USA.

Current Opinion in Anaesthesiology
|October 3, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Special Issue on new therapeutic approaches to Parkinson disease.

Neuropharmacology·2022
Same author

The selective 5-HT<sub>1A</sub> receptor agonist, NLX-112, exerts anti-dyskinetic effects in MPTP-treated macaques.

Parkinsonism & related disorders·2020
Same author

Inactivation of the bacterial pathogens Staphylococcus pseudintermedius and Acinetobacter baumannii by butanoic acid.

Journal of applied microbiology·2018
Same author

Doctor--how quickly will my Parkinson's progress?

European journal of neurology·2014
Same author

Preface.

Environmental monitoring and assessment·2013
Same author

Palliative care for advanced Parkinson disease: an interdisciplinary clinic and new scale, the ESAS-PD.

Parkinsonism & related disorders·2012
Same journal

The evolution of nonoperating room anesthesia: navigating a new frontier.

Current opinion in anaesthesiology·2026
Same journal

Enhanced recovery pathways for patients with chronic pain: beyond standard protocols - a narrative review.

Current opinion in anaesthesiology·2026
Same journal

Novel technologies and innovations in postoperative follow-up after regional anesthesia.

Current opinion in anaesthesiology·2026
Same journal

Regional anaesthesia and analgesia in surgical patients with chronic preoperative pain: mechanisms, evidence, and clinical implications.

Current opinion in anaesthesiology·2026
Same journal

Retention in pain care and research: a narrative review focused on implanted medical devices.

Current opinion in anaesthesiology·2026
Same journal

Airway ultrasound in patients undergoing head and neck surgery.

Current opinion in anaesthesiology·2026
See all related articles

Controlling gastrointestinal issues like reperfusion injury and maintaining gut barrier integrity may prevent multiple-organ system failure. Early intervention can reduce the incidence and severity of this critical condition.

Area of Science:

  • Critical care medicine
  • Gastroenterology
  • Immunology

Background:

  • Multiple-organ system failure (MOSF) is a severe complication of critical illness, often following major injury or infection.
  • Current treatments for MOSF primarily focus on supporting failing end-organs.
  • The gastrointestinal tract and systemic inflammation play key roles in MOSF development.

Purpose of the Study:

  • To explore preventative strategies for multiple-organ system failure.
  • To investigate the role of gastrointestinal tract integrity in MOSF pathophysiology.
  • To identify interventions that could reduce MOSF incidence and prevalence.

Main Methods:

  • Review of recent studies on MOSF pathophysiology.
  • Analysis of the impact of controlling reperfusion injury.

Related Experiment Videos

  • Assessment of methods to normalize gastrointestinal blood flow.
  • Evaluation of strategies to preserve gastrointestinal immune barrier integrity.

    • Main Results:

    • Emerging evidence suggests that interventions targeting the gastrointestinal tract can be effective.
    • Controlling the reperfusion injury cascade shows promise in preventing MOSF.
    • Maintaining normal gastrointestinal blood flow is crucial.
    • Preserving the gastrointestinal immune barrier integrity is a key factor.

    Conclusions:

    • Preventing multiple-organ system failure may be achievable by addressing gastrointestinal dysfunction.
    • Interventions focused on the gastrointestinal tract offer a novel approach to MOSF management.
    • Further research into gastrointestinal-focused therapies is warranted to reduce MOSF.