Modified haemoglobins and perfluorocarbons
1Department of Anaesthesiology and Critical Care Medicine, Faculty of Clinical Medicine Mannheim, Ruprecht-Karls-University Heidelberg, Mannheim, Germany. km20@rumms.uni-mannheim.de
Current Opinion in Anaesthesiology
|October 3, 2006
Summary
Artificial oxygen carriers, developed over decades, are nearing clinical use for severe hemorrhage. While not replacing blood transfusions, they offer rapid oxygen delivery, potentially expanding to other medical emergencies.
Area of Science:
- Biomedical Engineering
- Emergency Medicine
- Hematology
Background:
- Artificial oxygen carriers (AOCs) have undergone extensive research and development.
- Key technologies include hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon emulsions (PFCs).
- These advanced products are now in clinical investigation stages.
Purpose of the Study:
- To review the current development stage of artificial oxygen carriers.
- To discuss their potential impact on fluid resuscitation and trauma management.
- To explore future therapeutic indications for AOCs.
Main Methods:
- Review of decades of research and product improvements in HBOCs and PFCs.
- Analysis of current clinical investigations involving AOCs.
- Discussion of the physiological role and potential applications of AOCs.
Main Results:
- Artificial oxygen carriers are at a critical stage of development, with various HBOCs and PFCs in clinical trials.
- AOCs show potential to significantly alter hemorrhage management by bridging transfusion delays.
- Further research is investigating their efficacy in compromised circulation and broader medical applications.
Conclusions:
- Artificial oxygen carriers will not replace human blood transfusions but will complement them in trauma care.
- AOCs offer a vital solution for rapid tissue oxygenation during severe hemorrhage.
- Potential for expanded use in emergency medicine, trauma anesthesia, and other specialties exists with safe and effective AOCs.
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