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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by sustained extreme cold exposure, and severe...
Methods of reducing fever01:22

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Types of Fever01:25

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

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Related Experiment Video

Updated: Jul 19, 2026

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
13:41

Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

Published on: January 13, 2023

Malignant hyperthermia: advances in diagnostics and management.

P J Adnet1, G A Gronert

  • 1Service d'Accueil et d'Urgence, Hôpital R. Salengro, CHRU Lille, 59037 Lille Cedex, France. p-adnet@chru-lille.fr

Current Opinion in Anaesthesiology
|October 3, 2006
PubMed
Summary

Real-time monitoring of end-tidal carbon dioxide (ETCO2) during anesthesia detects malignant hyperthermia early. This monitoring, along with dantrolene treatment, helps manage skeletal muscle hypermetabolism.

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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
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Area of Science:

  • Anesthesiology
  • Pharmacology
  • Critical Care Medicine

Background:

  • Malignant hyperthermia (MH) is a life-threatening pharmacogenetic disorder of skeletal muscle.
  • Early detection of MH is crucial for effective management and improved patient outcomes.
  • End-tidal carbon dioxide (ETCO2) monitoring is a standard practice in anesthesia.

Purpose of the Study:

  • To highlight the utility of real-time ETCO2 monitoring in the early diagnosis of malignant hyperthermia.
  • To emphasize the role of ETCO2 changes in detecting MH before significant temperature elevation.
  • To underscore the efficacy of dantrolene in reversing MH-induced skeletal muscle hypermetabolism.

Main Methods:

  • Continuous monitoring of end-tidal carbon dioxide (ETCO2) during anesthetic procedures.
  • Observation of ETCO2 trends in conjunction with heart rate and core temperature.
  • Administration of dantrolene upon suspicion of malignant hyperthermia.

Main Results:

  • A rapid increase in ETCO2, coupled with unexplained tachycardia, preceded core temperature elevation in MH cases.
  • Real-time ETCO2 monitoring facilitated earlier identification of potential MH events.
  • Dantrolene administration effectively reversed the hypermetabolic state associated with MH.

Conclusions:

  • Real-time ETCO2 monitoring is a valuable tool for the early detection of malignant hyperthermia during anesthesia.
  • Prompt recognition of ETCO2 changes allows for timely intervention, potentially preventing severe hyperthermia.
  • Dantrolene remains the primary pharmacologic agent for reversing malignant hyperthermia.