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Updated: Jul 19, 2026

How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging
Published on: June 3, 2013
Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity
P M Fisher1, C C Meltzer, S K Ziolko
1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA.
Abstract:
We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level-dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30-44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.
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