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Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
Published on: January 12, 2024
An Asian patient with intraocular lymphoma treated by intravitreal methotrexate
Jia-Kang Wang1, Chung-May Yang2, Chang-Ping Lin3
1Department of Ophthalmology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Background:
To demonstrate the efficacy of intravitreal methotrexate for treating intraocular lymphoma.
Case:
A 55-year-old immunocompetent Asian man was diagnosed with intraocular lymphoma.
Observations:
The patient was initially managed by intravenous administration of high-dose methotrexate. Because vitreous cells persisted after systemic chemotherapy, methotrexate was given intravitreally thereafter. There was only self-limited corneal epitheliopathy without major complications following intraocular injections. Ocular remission was sustained during a 21-month follow-up.
Conclusion:
Intravitreal methotrexate is an effective, repeatable, and safe treatment for intraocular lymphoma.
