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Updated: Jul 19, 2026
12:49
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Living-donor liver transplantation: an overview
1University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, 4102, Australia.
Journal of Hepato-Biliary-Pancreatic Surgery
|October 3, 2006
Summary
Living-donor liver transplants are widely accepted, especially parent-to-child. However, adult-to-adult living-donor liver transplants show suboptimal survival rates and significant donor risks, questioning their expansion.
Area of Science:
- Hepatology
- Transplant Surgery
- Organ Transplantation
Background:
- Parent-to-child living-donor liver transplantation (LDLT) has been successful for 16 years.
- LDLT is widely accepted due to good outcomes and low donor risks in pediatric cases.
- Adult-to-adult LDLT has evolved but faces challenges.
Purpose of the Study:
- To evaluate the outcomes of adult-to-adult living-donor liver transplantation.
- To assess the risk-benefit analysis of expanding adult-to-adult LDLT.
- To compare LDLT outcomes with deceased donor liver transplantation.
Main Methods:
- Registry data analysis of recipient and graft survival rates.
- Review of donor morbidity and mortality rates in adult-to-adult LDLT.
- Comparative analysis of outcomes between LDLT and deceased donor liver transplantation.
Main Results:
- Despite LDLT recipients being better-risk candidates, overall survival rates are suboptimal.
- Adult-to-adult LDLT is associated with significant donor morbidity and mortality.
- Registry data indicates unsatisfactory long-term outcomes for adult-to-adult LDLT.
Conclusions:
- The expansion of adult-to-adult LDLT is difficult to justify based on current risk-benefit analysis.
- Improvements in surgical techniques and donor safety are needed for adult-to-adult LDLT.
- Further research is required to optimize outcomes in adult LDLT.
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