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Related Experiment Videos

Intermittent interferonemia and interferon responses in multiple sclerosis.

P J Hertzog1, A Wright, G Harris

  • 1Centre for Molecular Biology and Medicine, Monash University, Clayton, Victoria, Australia.

Clinical Immunology and Immunopathology
|January 1, 1991
PubMed
Summary

Multiple sclerosis patients exhibit abnormal interferon (IFN) production and response. Intermittent interferonemia and reduced leukocyte responses suggest unique viral or autoimmune triggers in MS, impacting potential IFN therapy.

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Area of Science:

  • Immunology
  • Virology
  • Neurology

Background:

  • Interferons (IFNs) possess crucial immunoregulatory and antiviral functions.
  • Multiple Sclerosis (MS) is characterized by autoimmune features and potential viral involvement.
  • Assessing IFN production and response is vital for understanding MS pathogenesis.

Purpose of the Study:

  • To evaluate in vivo and in vitro interferon (IFN) production and response in multiple sclerosis (MS) patients.
  • To investigate potential abnormalities in IFN pathways related to MS.
  • To explore the implications of these findings for IFN-based MS therapies.

Main Methods:

  • Serum IFN levels were measured using bioassays over 18 months in 42 MS patients.
  • Neutralization assays identified IFN types (IFN-alpha, IFN-gamma).

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  • Activity of IFN-induced enzyme 2'-5' oligoadenylate synthetase (OAS) and leukocyte IFN production in vitro were assessed.

    • Main Results:

    • 37 out of 42 MS patients showed detectable serum IFN (interferonemia), predominantly IFN-alpha.
    • A subset of patients displayed impaired leukocyte response to endogenous IFN.
    • Reduced capacity of peripheral blood leukocytes (PBL) to produce IFNs in vitro was observed in most patients.
    • These IFN abnormalities did not correlate with clinical disease activity.

    Conclusions:

    • MS patients exhibit distinct abnormalities in interferonemia and leukocyte IFN responses.
    • These findings suggest unusual triggers or responses to IFNs in MS.
    • The observed IFN dysregulation may influence the efficacy and scheduling of interferon therapy in MS.