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Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice

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Differential responsiveness to fluoxetine during puberty.

Kereshmeh Taravosh-Lahn¹, Christel Bastida, Yvon Delville

¹Institute for Neuroscience and Psychology Department, University of Texas at Austin, Austin, TX 78712, USA. kereshmeh@mail.utexas.edu

Behavioral Neuroscience

|October 4, 2006

Summary

During puberty, the serotonin system matures in male hamsters, influencing aggressive behavior development. This study investigated how serotonin impacts aggression during this critical developmental period.

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Area of Science:

Neuroscience
Behavioral Biology
Developmental Psychology

Background:

Aggressive behavior in male golden hamsters decreases during puberty.
Serotonin is known to inhibit offensive responses in adult hamsters.
A hypothesis suggests serotonin system upregulation in the hypothalamus during puberty.

Purpose of the Study:

To investigate the role of the serotonin system in the development of aggressive behavior during puberty in male golden hamsters.
To examine the effects of fluoxetine, a serotonin reuptake inhibitor, on aggressive responses in juvenile and adult hamsters.
To analyze developmental changes in hypothalamic serotonin innervation density.

Main Methods:

Acute administration of fluoxetine (serotonin reuptake inhibitor) to juvenile and adult male hamsters.
Behavioral analysis of attack frequency, repetition, and targets.
Quantification of serotonin innervation density in specific brain areas, particularly the hypothalamus.

Main Results:

In adult hamsters, fluoxetine inhibited aggressive behavior.
In juvenile hamsters, high-dose fluoxetine reduced offensive responses, while low-dose fluoxetine enhanced them.
Juveniles exhibited dose-specific maturation of attack targets.
Adult hamsters showed a 20% higher density of hypothalamic serotonin innervation compared to juveniles.

Conclusions:

The developing serotonergic system plays a crucial role in shaping the development of offensive behaviors in male golden hamsters.
Serotonin system maturation, including increased hypothalamic innervation, correlates with the pubertal decrease in aggression.
Fluoxetine's differential effects in juveniles suggest a complex, dose-dependent role of serotonin during development.