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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Transcytosis of IgG01:15

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
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Cross-reactivity

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Related Experiment Video

Updated: Jul 19, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Relationship between maternal- and fetal-specific IgE.

Enrico Bertino1, Carolina Bisson, Claudio Martano

  • 1Neonatal Unit, Department of Pediatric Sciences, University of Turin, Piazza Polonia 94, Turin, Italy. enrico.bertino@unito.it

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|October 4, 2006
PubMed
Summary

Maternal and fetal specific IgE levels against cow's milk proteins are closely correlated. This suggests fetal IgE production may depend on maternal IgE presence and allergen exposure.

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Isolation of Leukocytes from the Human Maternal-fetal Interface
08:19

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Related Experiment Videos

Last Updated: Jul 19, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

Isolation of Leukocytes from the Human Maternal-fetal Interface
08:19

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Area of Science:

  • Immunology
  • Allergy Research
  • Maternal-Fetal Medicine

Background:

  • Maternal and cord-blood IgE correlations are known for total IgE but not specific IgE.
  • Low concentrations of specific cord-blood IgE limit detection by standard methods.

Purpose of the Study:

  • To correlate maternal and fetal specific IgEs against individual cow's milk proteins.
  • To utilize highly sensitive and specific detection techniques for accurate measurement.

Main Methods:

  • Cow's milk specific IgE detection using chemiluminescence in maternal and cord blood.
  • Cow's milk protein separation via 1D and 2D gel electrophoresis.
  • Antigen identification using mass spectrometry.

Main Results:

  • Specific IgEs for cow's milk proteins detected in 48.1% of maternal and 37% of cord blood.
  • Identified proteins included BSA, IgG heavy chain, caseins, and b-lactoglobulin.
  • Positive cord-blood IgE responses consistently correlated with maternal responses.

Conclusions:

  • A strong relationship exists between maternal and cord-blood specific IgE patterns.
  • This finding may inform the understanding of fetal IgE production mechanisms.
  • Fetal IgE production might necessitate both maternal IgE and allergen presence.