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Dactinomycin-induced, severe lichenoid eruption in a child

V Ridola1, E Mahé, O Fawaz

  • 1Department of Pediatric Oncology, Gustave Roussy Institute, Villejuif, France.

Pediatric Dermatology
|October 4, 2006
PubMed

Insights

Dactinomycin can cause severe skin rashes, even without radiation therapy. This case highlights a child

Area of Science:

  • Oncology
  • Dermatology
  • Pediatric Oncology

Background:

  • Limited data exists on dactinomycin-induced skin rashes without radiotherapy.
  • Dactinomycin is a chemotherapy agent used in various pediatric cancers.

Observation:

  • A 12-month-old male experienced a severe, widespread, pruritic papular eruption and fever post-dactinomycin.
  • The patient presented with a poor general state.

Findings:

  • Skin biopsy confirmed a lichenoid eruption.
  • Topical steroid treatment led to rash improvement.
  • Complete resolution occurred within one month, with residual hyperpigmentation.

Implications:

  • Dactinomycin-induced cutaneous reactions are possible without concurrent radiotherapy.
  • Prompt diagnosis and management, including topical steroids, can resolve these reactions.
  • Discontinuation of dactinomycin may be necessary for severe cutaneous adverse events.

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