Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Significance of Membrane Transport01:44

The Significance of Membrane Transport

The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
The Significance of Membrane Transport01:44

The Significance of Membrane Transport

The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
Membrane Transporters01:31

Membrane Transporters

Transporters are essential membrane transport proteins with functions related to cell nutrition, homeostasis, communication, etc. Approximately 7% of all genes in the human genome code for transporters or transporter-related proteins.
Transporters are mainly composed of alpha-helices, built from bundles of ten or more helices traversing the plasma membrane. The solute-binding sites are located midway, where some of the helices are broken or distorted, making space for the binding site through...
Facilitated Diffusion01:16

Facilitated Diffusion

The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
Membrane Asymmetry Regulating Transporters01:19

Membrane Asymmetry Regulating Transporters

Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

V-ATPase a3 Directs Secretory Lysosome Transport in Enamel Formation.

Journal of dental research·2026
Same author

Electrohydrodynamics of diffuse porous colloids.

Soft matter·2024
Same author

Loss of Autophagy Disrupts Stemness of Ameloblast-Lineage Cells in Aging.

Journal of dental research·2023
Same author

Diffusiophoresis of Weakly Charged Fluid Droplets in a General Electrolyte Solution: An Analytical Theory.

Langmuir : the ACS journal of surfaces and colloids·2023
Same author

Cuspal Shape Alterations by Bmp4 Directing Cell Proliferation and Apoptosis.

Journal of dental research·2023
Same author

Electrophoresis of Dielectric and Hydrophobic Spherical Fluid Droplets Possessing Uniform Surface Charge Density.

Langmuir : the ACS journal of surfaces and colloids·2022

Related Experiment Video

Updated: Jul 19, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
19:56

Introduction to Solid Supported Membrane Based Electrophysiology

Published on: May 11, 2013

Further studies on membrane transport with time delay.

H Ohshima1, M Kamei, T Kondo

  • 1Faculty of Pharmaceutical Sciences and Institute of Colloid and Interface Science, Science University of Tokyo, 12 Ichigaya Funagawara-machi, Shinjuku-ku, Tokyo 162 Japan.

Biophysical Chemistry
|December 1, 1991
PubMed
Summary

This study extends cell membrane transport theory by adding a time delay parameter. The fraction of delayed solutes significantly impacts the conditions for oscillatory permeation.

More Related Videos

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope
15:10

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope

Published on: October 9, 2014

Related Experiment Videos

Last Updated: Jul 19, 2026

Introduction to Solid Supported Membrane Based Electrophysiology
19:56

Introduction to Solid Supported Membrane Based Electrophysiology

Published on: May 11, 2013

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
11:55

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution

Published on: August 16, 2016

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope
15:10

From Fast Fluorescence Imaging to Molecular Diffusion Law on Live Cell Membranes in a Commercial Microscope

Published on: October 9, 2014

Area of Science:

  • Biophysics
  • Chemical Engineering
  • Membrane Transport Phenomena

Background:

  • Existing theories on cell membrane transport.
  • The role of time delays in solute permeation.
  • Previous models predicting overshoot or oscillatory permeation.

Purpose of the Study:

  • To extend the existing theory of cell membrane transport with time delay.
  • To investigate the impact of a new parameter representing delayed solutes within the cell.
  • To analyze the conditions leading to oscillatory permeation.

Main Methods:

  • Mathematical modeling of cell membrane transport.
  • Introduction of a parameter for the fraction of delayed intracellular solutes.
  • Analysis of the theoretical model to determine oscillation criteria.

Main Results:

  • The criterion for oscillatory permeation is strongly dependent on the introduced parameter.
  • Demonstration of how the fraction of delayed solutes influences transport dynamics.
  • Exploration of results for an exponential-type distribution of delay times.

Conclusions:

  • The fraction of intracellular solutes experiencing time delay is a critical factor in cell membrane transport oscillations.
  • The extended model provides a more nuanced understanding of permeation dynamics.
  • Further analysis with varied delay time distributions can reveal complex transport behaviors.