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Related Experiment Videos

[Does midazolam release histamine?].

T Nishiyama1, Y Odaka, K Seto

  • 1Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu.

Masui. the Japanese Journal of Anesthesiology
|October 1, 1990
PubMed
Summary
This summary is machine-generated.

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Midazolam induction may reduce histamine release during anesthesia, but does not significantly alter gastric juice volume or pH. This study investigated midazolam

Area of Science:

  • Anesthesiology and Pharmacology
  • Gastroenterology

Context:

  • Anesthesia induction agents can influence physiological responses, including histamine release and gastric secretion.
  • Understanding these effects is crucial for patient safety, particularly regarding aspiration risk.

Purpose:

  • To evaluate the impact of midazolam as an induction agent on serum histamine levels.
  • To assess the effects of midazolam induction on gastric juice volume and pH.

Summary:

  • Study 1: Serum histamine levels were measured post-intubation in groups receiving midazolam or thiamylal for anesthesia induction. While no overall significant inter-group difference was found, the midazolam group showed a significant decrease in histamine levels at 30 minutes compared to pre-induction levels.
  • Study 2: Gastric juice volume and pH were measured in both groups. No significant differences were observed between midazolam and thiamylal groups in either gastric juice volume or pH.

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  • Conclusion: Midazolam may have a histamine-reducing effect, but it does not appear to clinically influence gastric juice secretion.

    • Impact:

    • Provides insights into the specific physiological effects of midazolam during anesthesia induction.
    • Suggests that midazolam may not increase the risk of aspiration due to altered gastric secretion.
    • Informs anesthetic practice regarding the choice of induction agents and their potential side effects.