Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuronal polarity in CNS development.

David J Solecki1, Eve-Ellen Govek, Toshifumi Tomoda

  • 1Laboratory of Developmental Neurobiology, The Rockefeller University, New York, New York 10021, USA.

Genes & Development
|October 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular Characterization of the Progressive Landscape of Depression.

bioRxiv : the preprint server for biology·2026
Same author

Long-term maintenance of H3K27me3 in postmitotic neurons is dispensable for gene expression regulation.

bioRxiv : the preprint server for biology·2026
Same author

An Interpretable 3D Bag-Of-Visual-Words Pipeline for Volumetric Microscopy Classification.

bioRxiv : the preprint server for biology·2026
Same author

ASTN2 in ASD and neurodevelopmental disorders.

Current topics in developmental biology·2026
Same author

Autophagy in Stress-Induced Neuropsychiatric Disorders and Depression.

JAMA psychiatry·2025
Same author

Optimizing multifunctional fluorescent ligands for intracellular labeling.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

Corrigendum: Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice.

Genes & development·2026
Same journal

A new perspective on ATR's role in translesion synthesis.

Genes & development·2026
Same journal

Mechanisms coordinating exit from the stem cell state in mammals.

Genes & development·2026
Same journal

Evolutionarily conserved spliceosome-exosome pathway in nuclear mRNA surveillance.

Genes & development·2026
Same journal

CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning.

Genes & development·2026
Same journal

Coupling of translesion synthesis with the replisome stabilized at stalled replication forks by ATR.

Genes & development·2026
See all related articles

Neuronal polarity, crucial for brain complexity, is regulated by conserved partitioning-defective (PAR) proteins. This review explores how these proteins establish polarity in developing mammalian brains.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Mammalian brain development features diverse neuronal morphologies and complex synaptic connections, highlighting the importance of cell polarity.
  • The discovery of partitioning-defective (PAR) proteins and their conserved roles in polarity across species, from C. elegans to vertebrates, has spurred significant research into polarity pathways.

Purpose of the Study:

  • To review emerging genetic, molecular genetic, biochemical, and cell biological approaches controlling neuronal polarity.
  • To define the role of conserved polarity proteins in generating neuronal diversity and connection patterns in the developing mammalian brain.

Main Methods:

  • Review of recent studies utilizing genetic and molecular genetic techniques.
  • Integration of biochemical and cell biological findings.

Related Experiment Videos

  • Focus on model systems including the neonatal cerebellum and hippocampus.

    • Main Results:

    • Identification of conserved polarity protein complexes, including PAR proteins, involved in establishing cell polarity.
    • Evidence suggests these conserved mechanisms play a critical role in neuronal development.
    • Emerging approaches offer new insights into the regulation of neuronal polarity.

    Conclusions:

    • Conserved polarity mechanisms, particularly involving PAR proteins, are fundamental to neuronal development in the mammalian brain.
    • Understanding these pathways is key to deciphering the generation of diverse cell types and synaptic connections.
    • Further research using model systems like the cerebellum and hippocampus will illuminate the precise roles of polarity proteins.