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Related Experiment Videos

[The mast cell].

T Knudsen1, T Johansen

  • 1Odense Universitet, Institut for Medicinsk Biologi.

Ugeskrift for Laeger
|November 19, 1990
PubMed
Summary
This summary is machine-generated.

Mast cells, key immune cells, release histamine and inflammatory mediators. Their secretion is triggered by both immune responses and non-immune factors, involving crucial calcium signaling pathways.

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Area of Science:

  • Immunology
  • Cell Biology

Context:

  • Mast cells are crucial immune cells found in connective tissues.
  • They contain granules storing histamine and other inflammatory mediators.

Purpose:

  • To review the morphological and functional characteristics of mast cells.
  • To elucidate the mechanisms of histamine secretion.

Summary:

  • Mast cells are ovoid cells with heparin-containing granules that stain metachromatically.
  • Histamine secretion occurs via exocytosis, triggered by immunological stimuli (antigen-IgE binding) or non-immunological factors (amines, neuropeptides).
  • Both extracellular and intracellular calcium stores are vital for histamine release, influenced by signaling molecules like phosphatide inositides and protein kinase C.

Impact:

  • Provides a comprehensive overview of mast cell function.
  • Highlights the complex signaling pathways regulating histamine release.
  • Informs research on allergic reactions and inflammatory processes.