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Related Concept Videos

Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
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Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Depressive Disorders: MDD and Dysthymia

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Treatment Strategies for Psychological Disorders01:24

Treatment Strategies for Psychological Disorders

Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
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Depressive Disorders: Etiology

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Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
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Depression decision support in primary care: a cluster randomized trial.

Steven K Dobscha1, Kathryn Corson, David H Hickam

  • 1Portland Veterans Affairs Medical Center, Oregon Health & Science University, and Oregon State University, Portland, Oregon 97207, USA. steven.dobscha@va.gov

Annals of Internal Medicine
|October 4, 2006
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Decision support for depression care did not improve patient outcomes in primary care. While satisfaction and treatment rates increased, depression symptom scores remained unchanged, suggesting a need for more intensive interventions.

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Area of Science:

  • Primary care research
  • Mental health services research
  • Clinical decision support systems

Background:

  • Intensive collaborative interventions show promise for improving depression outcomes.
  • The effectiveness of less intensive interventions, such as decision support, remains unclear.

Purpose of the Study:

  • To evaluate the impact of a decision support system on depression outcomes among primary care patients.
  • To assess secondary outcomes including quality-of-life, patient satisfaction, and healthcare utilization.

Main Methods:

  • A clinician-level, cluster randomized controlled trial was conducted across 5 primary care clinics.
  • 375 patients with moderate depression (PHQ-9 scores 10-25 or SCL-20 scores ≥1.0) were included.
  • Clinicians received depression education; some were randomized to receive depression decision support from a dedicated team.

Main Results:

  • No significant difference in depression symptom scores (SCL-20) was observed between the decision support and usual care groups at 6 or 12 months.
  • Patients receiving decision support reported higher satisfaction and were more likely to receive antidepressant treatment and mental health specialty care.
  • Health-related quality-of-life (SF-36V) scores did not differ between the groups.

Conclusions:

  • Decision support interventions can improve care processes, such as patient satisfaction and treatment adherence.
  • The current decision support model did not significantly improve depression outcomes, potentially due to concurrent high-quality usual care.
  • More intensive care management or direct specialty mental health treatment may be necessary to achieve better depression outcomes.