Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Hepatic Encephalopathy01:29

Hepatic Encephalopathy

DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging the diagnostic gap: the role of culture methods in the era of syndromic panels for central nervous system infections.

Frontiers in cellular and infection microbiology·2026
Same author

High-Resolution Genomic Surveillance of Carbapenem-Resistant <i>Acinetobacter baumannii</i>: IC-2 Clonal Diversity, Resistance Determinants, and Virulence Signatures.

Antibiotics (Basel, Switzerland)·2026
Same author

Managing Pneumonia Due to Rare Non-Fermenting Gram-Negative Bacteria: Epidemiology, Risk Factors and Therapeutic Strategies.

Antibiotics (Basel, Switzerland)·2026
Same author

ING Proteins and Neural Development in Newborns from Alcohol- and/or Drug-Abusing Pregnant Women.

International journal of molecular sciences·2026
Same author

Computational GWAS Meta Meta Analysis Revealing Cross Talk Between Cannabis CNR1 and DRD2 Receptors Optimizing Long-Term Outcomes for Cannabis Use Disorder (CUD) By Enhancing Dopamine Homeostasis Promoting High-Quality Cannabis Medicinals.

Research square·2025
Same author

Molecular exploration of host-pathogen interactions in severe <i>Pseudomonas aeruginosa</i> infection through a multi-level data integration approach.

Frontiers in medicine·2025

Related Experiment Video

Updated: Jul 19, 2026

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

Acute alcoholic hepatitis.

Mauro Ceccanti1, Adolfo Attili, Giuseppe Balducci

  • 1Alcohol Liver Disease Unit, University "La Sapienza", Roma, Italy. mauro.ceccanti@uniroma1.it

Journal of Clinical Gastroenterology
|October 4, 2006
PubMed
Summary

Acute alcoholic hepatitis (AAH) is a serious liver condition. This review covers its causes, prognosis using scores like MELD, and treatments including steroids for severe cases.

More Related Videos

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

Related Experiment Videos

Last Updated: Jul 19, 2026

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

Area of Science:

  • Hepatology
  • Immunology
  • Gastroenterology

Background:

  • Acute alcoholic hepatitis (AAH) is a prevalent inflammatory liver disease associated with significant short-term mortality.
  • Alcohol abuse is a primary driver of AAH, impacting its epidemiology and patient outcomes.

Purpose of the Study:

  • To review the epidemiology, pathogenesis, prognosis, and treatment of acute alcoholic hepatitis.
  • To discuss the role of specific inflammatory mediators and immune responses in AAH.
  • To outline management strategies, including prognostic scoring and therapeutic interventions.

Main Methods:

  • Literature review focusing on alcohol abuse, AAH epidemiology, pathogenesis, and outcomes.
  • Discussion of key pathogenetic factors: endotoxins, tumor necrosis factor alpha, fibroblasts, and immune response.
  • Analysis of prognostic scoring systems: Maddrey score, MELD score, and Glasgow alcoholic hepatitis score.
  • Evaluation of treatment options: glucocorticoids and infliximab for severe AAH.

Main Results:

  • AAH pathogenesis involves endotoxins, TNF-alpha, fibroblasts, and immune responses to altered hepatocytes.
  • Prognostic scores (Maddrey, MELD, Glasgow) are crucial for assessing AAH severity.
  • Glucocorticoids and anti-TNF-alpha infliximab are recommended for severe AAH.
  • Liver transplantation for severe AAH requires 6-month alcohol abstinence and psychological assessment.

Conclusions:

  • Effective management of AAH necessitates accurate prognosis and targeted therapy.
  • Severe AAH cases benefit from specific treatments like glucocorticoids and infliximab.
  • Liver transplantation in AAH patients demands strict adherence to abstinence and psychological evaluation.