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Related Concept Videos

General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia01:30

Local Anesthetics: Clinical Application as Surface, Infiltration, and Conduction Block Anesthesia

Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...

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Related Experiment Video

Updated: Jul 19, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
08:49

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

Combined regional and general anaesthesia.

N Rawal1

  • 1Department of Anaesthesiology and Intensive Care, Orebro Medical Centre Hospital, Orebro, Sweden. n.rawal@orebroll.se

Current Opinion in Anaesthesiology
|October 4, 2006
PubMed
Summary

Combining regional and general anesthesia offers benefits for major surgeries, especially in children. While regional techniques provide prolonged pain relief, their superiority is debated for specific procedures like hip fracture surgery.

Related Experiment Videos

Last Updated: Jul 19, 2026

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
08:49

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

Area of Science:

  • Anesthesiology
  • Surgical Procedures
  • Pain Management

Background:

  • Combining regional and general anesthesia is advantageous for major thoracic, abdominal, and orthopedic surgeries.
  • Regional anesthesia in anesthetized children is standard due to needle phobias, anxiety, and cooperation issues.
  • Epidural anesthesia offers benefits like reduced sympathetic hyperactivity, maintained bowel function, opioid sparing, and improved postoperative recovery.

Purpose of the Study:

  • To review the combined use of regional and general anesthesia across various surgical procedures.
  • To compare the efficacy of regional versus general anesthesia, particularly in elderly patients.
  • To analyze recent studies disputing the superiority of regional techniques in specific surgeries.

Main Methods:

  • Review of studies published within the past year.
  • Focus on the combination of regional and general anesthesia.
  • Comparison of anesthetic techniques in elderly patients.

Main Results:

  • Regional anesthesia, via catheter techniques, provides prolonged postoperative analgesia.
  • Potential drawbacks of epidural blocks include decreased blood flow in free flap surgery and increased intrapulmonary shunting during one-lung ventilation.
  • The superiority of regional techniques for hip fracture surgery and carotid endarterectomy is currently debated.

Conclusions:

  • Combined regional and general anesthesia offers significant advantages in specific patient populations and surgical contexts.
  • Catheter-based regional techniques ensure excellent and extended postoperative pain management.
  • Careful consideration of potential complications and ongoing research are necessary to optimize anesthetic strategies.