Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Update on cardiopulmonary bypass.

G P Gravlee1

  • 1Department of Anesthesiology, The Ohio State University, College of Medicine and Public Health, Columbus, Ohio 43210, USA. gravlee.1@osu.edu

Current Opinion in Anaesthesiology
|October 4, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A dose-determining trial of heparinase-I (Neutralase) for heparin neutralization in coronary artery surgery.

Anesthesia and analgesia·2001
Same author

The clinical onset of heparin is rapid.

Anesthesia and analgesia·2001
Same author

Con: aprotinin should not be used in patients undergoing hypothermic circulatory arrest.

Journal of cardiothoracic and vascular anesthesia·2001
Same author

On aging, fast-tracking, and derailment in CABG patients.

Journal of cardiothoracic and vascular anesthesia·1998
Same author

Minimally invasive direct coronary artery bypass: anesthetic, monitoring, and pain control considerations.

Journal of cardiothoracic and vascular anesthesia·1998
Same author

Tranexamic acid reduces bleeding after cardiopulmonary bypass when compared to epsilon aminocaproic acid and placebo.

Journal of cardiac surgery·1998
Same journal

Phrenic-sparing strategies for shoulder surgery: balancing respiratory safety and block completeness.

Current opinion in anaesthesiology·2026
Same journal

The evolution of nonoperating room anesthesia: navigating a new frontier.

Current opinion in anaesthesiology·2026
Same journal

Enhanced recovery pathways for patients with chronic pain: beyond standard protocols - a narrative review.

Current opinion in anaesthesiology·2026
Same journal

Novel technologies and innovations in postoperative follow-up after regional anesthesia.

Current opinion in anaesthesiology·2026
Same journal

Regional anaesthesia and analgesia in surgical patients with chronic preoperative pain: mechanisms, evidence, and clinical implications.

Current opinion in anaesthesiology·2026
Same journal

Retention in pain care and research: a narrative review focused on implanted medical devices.

Current opinion in anaesthesiology·2026
See all related articles

Recent research on cardiopulmonary bypass highlights neurological complications and the potential neuroprotective effects of mild hypothermia. Studies also compare antifibrinolytic agents and explore inflammation management strategies.

Area of Science:

  • Cardiovascular Surgery
  • Neurology
  • Anesthesiology

Background:

  • Cardiopulmonary bypass (CPB) is a critical procedure with ongoing research into optimizing patient outcomes.
  • Neurological complications and inflammatory responses remain significant concerns following CPB.
  • Debates persist regarding optimal CPB management parameters, including temperature and hematocrit levels.

Purpose of the Study:

  • To review recent advancements in understanding and managing CPB.
  • To explore the role of genetic predisposition in CPB-related neurological complications.
  • To evaluate the efficacy of different temperature management strategies and antifibrinolytic agents.

Main Methods:

  • Review of recent meta-analyses and prospective investigations.

Related Experiment Videos

  • Analysis of studies investigating the mechanisms of CPB-induced inflammation.
  • Examination of research on neurological complications and potential risk factors.

    • Main Results:

    • Mild hypothermia post-CPB may offer neuroprotection, shifting focus from traditional temperature management debates.
    • Aprotinin and lysine analogues demonstrate comparable efficacy in reducing bleeding and transfusion needs.
    • Recent studies have elucidated the mechanisms and severity of the inflammatory response to CPB.

    Conclusions:

    • Continued investigation into CPB is refining clinical practice, particularly concerning neurological complications.
    • Optimizing CPB parameters like flow, pressure, and hematocrit remains an area of active research and controversy.
    • Strategies to attenuate the inflammatory response and manage neurological risks are crucial for improving CPB outcomes.