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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
Chronic migraine prevention with topiramate
Mario F P Peres1, Juliane P P Mercante, Fabiano C Tanuri
1Instituto Israelita de Ensino e Pesquisa Albert Einstein, UNIFESP - EPM FMABC, Department of Neurology, Brazil. marioperes@yahoo.com
The Journal of Headache and Pain
|October 4, 2006
Summary
Topiramate effectively reduces headache frequency in chronic migraine (CM) patients. This study found significant improvements, with 66% experiencing over 50% reduction in headaches, suggesting it is a viable CM prophylaxis option.
Area of Science:
- Neurology
- Clinical Pharmacology
Background:
- Chronic migraine (CM) is a debilitating neurological disorder with limited treatment options.
- Topiramate is established for episodic migraine prevention, but its efficacy in CM is less understood.
Purpose of the Study:
- To evaluate the effectiveness of topiramate in the prophylaxis of chronic migraine.
Main Methods:
- An open-label study enrolled 64 patients with CM or probable CM.
- Fifty patients were analyzed using an intention-to-treat approach.
- The primary endpoint was >50% reduction in headache frequency.
Main Results:
- A median dose of 100 mg topiramate was used.
- 66% of patients (33/50) achieved >50% reduction in headache frequency.
- 28% of patients (14/50) achieved a complete response (>95% frequency reduction).
Conclusions:
- Topiramate demonstrates significant efficacy in reducing headache frequency for chronic migraine patients.
- The medication was generally well-tolerated, with common side effects including weight loss and paraesthesias.
- Topiramate is a promising option for chronic migraine prophylaxis.
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