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Updated: Jul 19, 2026
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Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
The subiculum comes of age.
Liset Menendez de la Prida1, Susan Totterdell, John Gigg
1Neurobiología-Investigación, Hospital Ramón y Cajal, Madrid, Spain.
Hippocampus
|October 4, 2006
Summary
The subiculum, once thought a simple relay, plays specific roles in cognition and hippocampal disorders. Recent research highlights its complex neurobiology, anatomy, and pathology.
Area of Science:
- Neuroscience
- Cognitive Science
Background:
- The subiculum is traditionally viewed as a relay between the hippocampus and temporal cortex.
- Emerging evidence indicates the subiculum's crucial involvement in cognitive functions and hippocampal pathologies.
Purpose of the Study:
- To review recent findings on the subiculum's neurobiology presented at a 2005 ESF-sponsored meeting.
- To consolidate diverse expertise on the subiculum's anatomy, physiology, psychology, and pathology.
Main Methods:
- A review of recent research findings presented by 20 experts.
- Synthesis of knowledge from various disciplines including anatomy, physiology, psychology, and pathology.
Main Results:
- The subiculum's role extends beyond simple relay functions.
- Specific cognitive functions and pathological deficits are linked to the subiculum.
Conclusions:
- The subiculum is a critical region with specific functions within the hippocampal formation.
- Further research is needed to fully elucidate the subiculum's complex neurobiological roles.
