Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 19, 2026

Laser Capture Microdissection of Mammalian Tissue
16:34

Laser Capture Microdissection of Mammalian Tissue

Published on: October 1, 2007

Laser-assisted microdissection (LAM) in developmental biology.

Nyam-Osor Chimge1, Frank Ruddle, Dashzeveg Bayarsaihan

  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.

Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution
|October 4, 2006
PubMed
Summary

Laser-assisted microdissection (LAM) precisely isolates cells from developing tissues for molecular analysis. This technology enhances understanding of gene expression and differentiation in developmental biology research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of DOT1L histone methyltransferase with non-syndromic orofacial clefts in a cohort of children of African and Asian ancestry.

medRxiv : the preprint server for health sciences·2026
Same author

Single-cell RNA analysis of chromodomain-encoding genes in mesenchymal stromal cells of the mouse dental pulp.

Journal of cellular biochemistry·2024
Same author

Targeting Wnt signaling for improved glioma immunotherapy.

Frontiers in immunology·2024
Same author

A Deeply Quiescent Subset of CML LSC depend on FAO yet Avoid Deleterious ROS by Suppressing Mitochondrial Complex I.

Current molecular pharmacology·2023
Same author

Differential Kat3 Coactivator Usage Regulates Brain Metabolism and Neuronal Differentiation.

Current molecular pharmacology·2023
Same author

E7386 is not a Specific CBP/β-Catenin Antagonist.

Current molecular pharmacology·2023

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genomics

Background:

  • Analyzing gene expression in developing organs is crucial for understanding genetic fingerprints during differentiation.
  • Biochemical processes in developing tissues are complex and challenging to study.
  • Laser-assisted microdissection (LAM) offers a precise method for cell isolation.

Purpose of the Study:

  • To provide an overview of Laser-assisted microdissection (LAM) technology.
  • To highlight the applications of LAM in developmental biology.
  • To discuss the advancements in cell isolation for molecular characterization.

Main Methods:

  • Laser-assisted microdissection (LAM) for precise cell capture.
  • Advanced tissue preparation and microextraction protocols.

More Related Videos

Laser Microdissection for Species-Agnostic Single-Tissue Applications
08:57

Laser Microdissection for Species-Agnostic Single-Tissue Applications

Published on: March 31, 2022

Laser-assisted Microdissection (LAM) as a Tool for Transcriptional Profiling of Individual Cell Types
09:31

Laser-assisted Microdissection (LAM) as a Tool for Transcriptional Profiling of Individual Cell Types

Published on: May 10, 2016

Related Experiment Videos

Last Updated: Jul 19, 2026

Laser Capture Microdissection of Mammalian Tissue
16:34

Laser Capture Microdissection of Mammalian Tissue

Published on: October 1, 2007

Laser Microdissection for Species-Agnostic Single-Tissue Applications
08:57

Laser Microdissection for Species-Agnostic Single-Tissue Applications

Published on: March 31, 2022

Laser-assisted Microdissection (LAM) as a Tool for Transcriptional Profiling of Individual Cell Types
09:31

Laser-assisted Microdissection (LAM) as a Tool for Transcriptional Profiling of Individual Cell Types

Published on: May 10, 2016

  • Molecular characterization of isolated cells (genomics, transcriptomics, proteomics).

    • Main Results:

    • LAM enables efficient and accurate isolation of specific cells from developing tissues.
    • The technique allows for molecular characterization within spatial and temporal contexts.
    • Improvements in LAM and associated protocols facilitate broad downstream applications.

    Conclusions:

    • LAM is a powerful tool for studying gene expression and differentiation in developmental biology.
    • Advancements in LAM have significantly improved the ease of isolating specific cells.
    • LAM supports diverse applications in genomics, transcriptomics, and proteomics for developmental studies.