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Updated: Jul 19, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
The use of evolutionary biology concepts for genome annotation
Etienne G J Danchin1, Anthony Levasseur, Virginie Lopez Rascol
1Glycogenomics and Biomedical Structural Biology, AFMB Laboratory, UMR 6098, CNRS, Universités d'Aix-Marseille I et II, 13288 Marseille, France.
Abstract:
The past decade has seen the completion of numerous whole-genome sequencing projects, began with bacterial genomes and continued with eukaryotic species from different phyla: fungi, plants and animals. Besides, more biological information are produced and are shared thanks to information exchange systems, and more biological concepts, as well as more bioinformatics tools, are available. In this article, we will describe how the evolutionary biology concepts, as well as computer science, are useful for a better understanding of biology in general and genome annotation in particular. The genome annotation process consists of taking the raw DNA produced, for example, by the genome sequencing projects, adding the layers of analysis and interpretation necessary to extract its biological significance and placing it in the context of our understanding of biological processes. Genome annotation is a multistep process falling into two broad categories: structural and functional annotation.
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