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Rubella seroprevalence among young women taipei county after routine measles, mumps and rubella immunization program

I-Jen Wang1, Kung-Chang Hwang, Ya-Huei Tsai

  • 1Department of Pediatrics, Taipei Hospital, Taipei, Taiwan.

Acta Paediatrica Taiwanica = Taiwan Er Ke Yi Xue Hui Za Zhi
|October 5, 2006
PubMed

Insights

High rubella immunity exists in Taiwanese children post-vaccination policy. However, older age, lower maternal education, and foreign mothers are linked to lower rubella seropositivity, indicating a need for targeted vaccination efforts.

Area of Science:

  • Immunology
  • Public Health
  • Epidemiology

Background:

  • The 1986 national vaccine policy aimed to increase rubella immunity in Taiwan.
  • Understanding current rubella seroprevalence is crucial for optimizing immunization strategies.

Purpose of the Study:

  • To determine age-specific rubella seroprevalence in Taiwanese children and adolescents.
  • To identify factors associated with rubella seropositivity after the national vaccination policy.
  • To inform targeted rubella immunization efforts.

Main Methods:

  • A cross-sectional study involving 826 girls aged 10 to 22 years in Taipei County, 2004.
  • Data collection via questionnaires on demographics, socioeconomic factors, and infection history.
  • Multivariate logistic regression analysis to identify predictors of rubella seropositivity.

Main Results:

  • High overall rubella seropositive rates observed across age groups (92.4%–99.6%).
  • Geometric mean titer of rubella IgG antibody was 60.7 IU/ml.
  • Seronegativity correlated with older age, low maternal education, and foreign maternal ethnicity (p < 0.05).

Conclusions:

  • The Measles, Mumps, and Rubella (MMR) vaccine program has effectively induced rubella immunity.
  • Targeted vaccination strategies are needed for susceptible adolescents and young women to eliminate congenital rubella syndrome.
  • Socioeconomic and demographic factors influence rubella immunity levels.

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